In sub-Saharan Africa, non-typhoidal Salmonella (NTS) can cause bloodstream infections, referred to as invasive non-typhoidal Salmonella disease (iNTS disease); it can occur in outbreaks and is often preceded by malaria. Data from Central Africa is limited.Clinical, microbiological and molecular findings of NTS recovered in a blood culture surveillance project (2009-2014) were analyzed.In March-July 2012 there was an epidemic increase in malaria infections in the Oriental Province of the Democratic Republic of the Congo (DRC). In one referral hospital, overall hospital admissions in June 2012 were 2.6 times higher as compared to the same period in the years before and after (336 versus an average of 128 respectively); numbers of malaria cases and blood transfusions were nearly three- and five-fold higher respectively (317 versus 112 and 250 versus 55). Case fatality rates (in-hospital deaths versus all admissions) peaked at 14.6%. Salmonella Typhimurium and Salmonella Enteritidis together accounted for 88.9% of pathogens isolated from blood cultures collected during an outreach visit to the affected districts in June 2012.

Children infected with Salmonella Enteritidis (33 patient files available) tended to be co-infected with Plasmodium falciparum more often than children infected with Salmonella Typhimurium (40 patients files available) (81.8% versus 62.5%). Through the microbiological surveillance project (May 2009-May 2014) 113 unique NTS isolates were collected (28.5% (113/396) of pathogens); most (95.3%) were recovered from children. Results In March-July 2012 there was an epidemic increase in malaria infections in the Oriental Province of the Democratic Republic of the Congo (DRC). In one referral hospital, overall hospital admissions in June 2012 were 2.6 times higher as compared to the same period in the years before and after (336 versus an average of 128 respectively); numbers of malaria cases and blood transfusions were nearly three- and five-fold higher respectively (317 versus 112 and 250 versus 55). Case fatality rates (in-hospital deaths versus all admissions) peaked at 14.6%. Salmonella Typhimurium and Salmonella Enteritidis together accounted for 88.9% of pathogens isolated from blood cultures collected during an outreach visit to the affected districts in June 2012. Children infected with Salmonella Enteritidis (33 patient files available) tended to be co-infected with Plasmodium falciparum more often than children infected with Salmonella Typhimurium (40 patients files available) (81.8% versus 62.5%).

Through the microbiological surveillance project (May 2009–May 2014) 113 unique NTS isolates were collected (28. Installation Routeur Olitec Rw400g there. 5% (113/396) of pathogens); most (95.3%) were recovered from children. Background In industrialized countries, non-typhoidal Salmonella (NTS, i.e., Salmonella serovars other than Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi) are associated with self-limiting diarrhea. In sub-Saharan Africa however, they often cause bloodstream infections, which is referred to as invasive non-typhoidal Salmonella disease (iNTS disease). They are among the pathogens most frequently isolated from blood cultures [–].

Laplink Usb 1.1 Driver Windows 7. In fact, iNTS disease poses an important public health problem with an estimated population-based annual incidence of 175–388 cases/100,000 in children aged 3–5 years of age []. Bell Gothic Std Black Black Western Font. Due to the lack of microbiological facilities in many African countries, the true burden of iNTS disease is not well known and the condition remains undiagnosed and hence invisible and neglected.

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